منابع مشابه
Lipid modifications of G-protein-coupled receptor kinases.
Introduction G-protein-coupled receptors recognize a wide variety of extracellular ligands and stimuli. These include hormones, neurotransmitters, neuromodulators, Ca2+ ions, tastants, odorants and photons [l-31. This family of receptors may number over 1000 members and is characterized by a seven-transmembrane-spanning architecture. Signal transmission is initiated by a receptor conformational...
متن کاملDifferential Localization of G Protein βγ Subunits
G protein βγ subunits play essential roles in regulating cellular signaling cascades, yet little is known about their distribution in tissues or their subcellular localization. While previous studies have suggested specific isoforms may exhibit a wide range of distributions throughout the central nervous system, a thorough investigation of the expression patterns of both Gβ and Gγ isoforms with...
متن کاملG protein fBy subunits stimulate phosphorylation of Shc adapter protein
The mechanism of mitogen-activated protein (MAP) kinase activation by pertussis toxin-sensitive G,coupled receptors is known to involve the fry subunits of heterotrimeric G proteins (Gfry), p2lraS activation, and an as-yet-unidentified tyrosine kinase. To investigate the mechanism of G8y-stimulated p2lras activation, Ggy-mediated tyrosine phosphorylation was examined by overexpressing GPy or a2...
متن کاملG alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.
Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) are central to the signaling processes of multicellular organisms. We have explored the diversity of the G protein subunits in mammals and found evidence for a large family of genes that encode the alpha subunits. Amino acid sequence comparisons show that the different alpha subunits fall into at least three classes. The...
متن کاملInhibition of Subsets of G Protein-coupled Receptors by Empty Mutants of G Protein a Subunits
We previously reported that the xanthine nucleotide binding Goa mutant, GoaX, inhibited the activation of Gi-coupled receptors. We constructed similar mutations in G11a and G16a and characterized their nucleotide binding and receptor interaction. First, we found that G11aX and G16aX expressed in COS-7 cells bound xanthine 5*-O-(thiotriphosphate) instead of guanosine 5*-O(thiotriphosphate). Seco...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1991
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)64372-1